Colorectal Cancer: A Major Health Concern

Colorectal cancer stands as the second leading cause of cancer-related deaths in the U.S. The good news is that early detection can significantly enhance survival rates. However, I, as an oncologist, find it disheartening that over one-third of adults between 50 and 75 years of age are not undergoing recommended screenings.

Modifiable Risk Factors

According to the American Cancer Society, several factors can be modified to reduce colorectal cancer risk:

• Excess Weight: Being overweight or obese
• Type 2 Diabetes: A significant risk factor
• Diet: A long-term diet heavy in red and processed meats, such as beef and hot dogs, can increase risk. Conversely, a diet rich in fruits, vegetables, and whole grains may help mitigate this risk. Limiting sugary beverages is also advisable.
• Smoking: A known risk factor for many cancers.
• Alcohol Consumption: The risk of colorectal cancer rises with alcohol intake; even moderate consumption may elevate risk. The safest approach is to avoid alcohol altogether or limit intake to no more than two drinks per day for men and one for women.

Fixed Risk Factors

Certain risk factors cannot be changed:

• Age: The likelihood of developing colorectal cancer increases with age.
• Race and Ethnicity: Some groups, such as American Indians, Alaska Natives, and African Americans, are at a higher risk.
• Sex at Birth: Men generally have a lower survival rate than women, and postmenopausal women are more prone to right-sided colon cancer. Research is ongoing to understand these disparities.
• Medical History: A personal history of colorectal polyps or inflammatory bowel disease increases risk.

ColoSense: A New Hope in Screening

I am thrilled to announce that the U.S. Food and Drug Administration has recently approved a groundbreaking new colorectal cancer screening test called ColoSense. This test uses stool analysis to detect colorectal cancer in adults aged 45 and older who are at average risk.

As I previously mentioned, while colonoscopies are crucial, they can be uncomfortable (ask anyone about the preparation involved). ColoSense offers a non-invasive and convenient alternative.

Gene Targets Identified for New Non-invasive Colorectal Cancer Screening Test - This video discusses the promising gene targets that could enhance the effectiveness of non-invasive tests like ColoSense.

How ColoSense Works

ColoSense relies on RNA analysis rather than DNA, offering a real-time insight into your body’s health. RNA levels fluctuate quickly, making it a more dynamic marker for early signs of trouble.

By focusing on RNA signals from the digestive tract, ColoSense provides a comprehensive analysis of potential problem areas, catching pre-cancerous lesions early.

Current Screening Recommendations

Let’s conclude with the screening guidelines from the U.S. Preventative Services Task Force (USPSTF) for individuals at average risk:

• Grade A: High certainty of substantial benefit.
• Grade B: Moderate certainty of moderate to substantial benefit.
• Grade C: Selective offering based on professional judgment and patient preference with moderate certainty of small benefit.

Screening for Older Adults

The USPSTF advises that clinicians selectively offer colorectal cancer screening to adults aged 76 to 85, as screening everyone in this age group yields only a modest net benefit.

The decision should take into account the patient’s overall health, prior screening history, and personal preferences.

Have you undergone colorectal screening?

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FDA Approves Blood Test for Colorectal Cancer Screening for Some Adults - This video covers the recent FDA approval of a new blood test for colorectal cancer screening, shedding light on its implications for patient care.